Clinical outcomes among patients with head and neck cancer treated by intensity‐modulated radiotherapy with and without adaptive replanning. Issue 11 (22nd January 2014)

• Record Type: Journal Article
• Authors: Chen, Allen M.; Daly, Megan E.; Cui, Jing; Mathai, Mathew; Benedict, Stanley; Purdy, James A.
• Is Part Of: Head & neck. Volume 36:Issue 11(2014:Nov.)
• Page Start: 1541
• Page End: 1546
• Publication Date: 2014-01-22
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23477
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23477-sec-0001" sec-type="section"> <title>Background</title> <p>The purpose of this study was to determine the effect of adaptive replanning on clinical outcome among patients treated by intensity‐modulated radiotherapy (IMRT) for head and neck cancer.</p> </sec> <sec id="hed23477-sec-0002" sec-type="section"> <title>Methods</title> <p>Three hundred seventeen patients underwent IMRT with daily image‐guidance for newly diagnosed squamous cell carcinoma of the head and neck to a median dose of 66 Gy (range, 60–74 Gy). Of these 317 patients, 51 (16%) underwent adaptive radiotherapy with modification of the original IMRT midway during treatment.</p> </sec> <sec id="hed23477-sec-0003" sec-type="section"> <title>Results</title> <p>The 2‐year local‐regional control was 88% for patients treated with adaptive replanning compared with 79% for patients treated without (<italic>p</italic> = .01). The median time to local‐regional recurrence for the 4 patients treated by adaptive radiotherapy was 7 months (range, 3–15 months) with all failures occurring within the high‐dose planning target volume (PTV).</p> </sec> <sec id="hed23477-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Although the use of routine replanning is probably not necessary, our findings do suggest a significant benefit in appropriately selected patients. © 2014 Wiley Periodicals, Inc. <italic>Head Neck</italic> 36: 1541–1546, 2014</p> </sec> </abstract>