Synthesis of Cross‐Linked Glycopeptides and Ureas by a Mechanochemical, Solvent‐Free Reaction and Determination of Their Structural Properties by TEM and X‐ray Crystallography. Issue 11 (12th August 2014)

• Record Type: Journal Article
• Authors: Kumar, Vajinder; Giri, Santosh Kumar; Venugopalan, Paloth; Kartha, K. P. Ravindranathan
• Is Part Of: ChemPlusChem. Volume 79:Issue 11(2014:Nov.)
• Page Start: 1605
• Page End: 1613
• Publication Date: 2014-08-12
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cplu.201402185
• Languages: English
• ISSNs: 2192-6506

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A highly efficient and cost‐effective green method for the synthesis of complex glycopeptides and ureas mediated by carbonyl diimidazole under solvent‐free conditions is reported. The reactions could be performed conveniently in a planetary ball mill by dry grinding, and the isolation of the novel sugar derivatives thus produced could be very efficiently achieved by size exclusion chromatography with environmentally benign substances. A diacetone galactose based diamide, upon crystallization, could be examined by X‐ray crystallography and was found to possess a heart‐shaped structure. Although the 4‐aminophenyl galactoside based diamide synthesized formed spherical particles, the alanine‐based diamide formed nanofilamentous/‐tubular structures as analyzed by TEM imaging.</p> </abstract>