Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells. Issue 12 (10th September 2014)

• Record Type: Journal Article
• Authors: Suberu, John O.; Romero‐Canelón, Isolda; Sullivan, Neil; Lapkin, Alexei A.; Barker, Guy C.
• Is Part Of: ChemMedChem. Volume 9:Issue 12(2014:Dec.)
• Page Start: 2791
• Page End: 2797
• Publication Date: 2014-09-10
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201402285
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>In parts of Africa and Asia, self‐medication with a hot water infusion of <italic>Artemisia annua</italic> (<italic>Artemisia</italic> tea) is a common practice for a number of ailments including malaria and cancer. In our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine‐sensitive and ‐resistant parasites. In this study, in vitro tests of the infusion in MCF7 cells showed high IC₅₀ values (&gt;200 μ<sc>M</sc>). The combination of artemisinin and 3‐caffeoylquinic acid (3CA), two major components in the extract, was strongly antagonistic and gave a near total loss of cytotoxicity for artemisinin. We observed that the interaction of 3CAs with another cytotoxic compound, cisplatin, showed potentiation of activity by 2.5‐fold. The chelation of cellular iron by 3CA is hypothesized as a possible explanation for the loss of artemisinin activity.</p> </abstract>