Copper‐Catalyzed Arylation of Nitrogen Heterocycles from Anilines under Ligand‐Free Conditions. Issue 45 (3rd October 2014)

• Record Type: Journal Article
• Authors: Toummini, Dounia; Tlili, Anis; Bergès, Julien; Ouazzani, Fouad; Taillefer, Marc
• Is Part Of: Chemistry. Volume 20:Issue 45(2014)
• Page Start: 14619
• Page End: 14623
• Publication Date: 2014-10-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201404982
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The arylation of pyrazole and derivatives can be achieved by coupling arenediazonium species (formed in situ from anilines) by using a catalytic system that employs low‐toxicity and inexpensive copper metal under very mild and ligand‐free conditions (<italic>T</italic>=20 °C). From other nitrogen heterocycles, the presence of an additive (NBu₄I) significantly improves the efficiency of the catalytic system. These results represent the first examples of CN bond formation from arenediazonium species.</p> </abstract>