Rhodium‐Catalyzed Arylative Cyclization for the Enantioselective Synthesis of (Trifluoromethyl)cyclobutanols. Issue 44 (18th September 2014)

• Record Type: Journal Article
• Authors: Johnson, Thomas; Choo, Ken‐Loon; Lautens, Mark
• Is Part Of: Chemistry. Volume 20:Issue 44(2014)
• Page Start: 14194
• Page End: 14197
• Publication Date: 2014-09-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201404896
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A rhodium‐catalyzed cyclization of 1‐(trifluoromethyl)‐4‐alkyn‐1‐ones with arylboronic acids is described to yield a novel class of small rings: (trifluoromethyl)cyclobutanols bearing an exocyclic double bond. The use of a rhodium/chiral diene complex allowed the reaction to proceed under mild conditions, often with high enantioselectivity. An X‐ray crystal structure was obtained confirming the formation of the four‐membered ring products.</p> </abstract>