A Bis(pyridine N‐oxide) Analogue of DOTA: Relaxometric Properties of the GdIII Complex and Efficient Sensitization of Visible and NIR‐Emitting Lanthanide(III) Cations Including PrIII and HoIII1. Issue 45 (18th September 2014)

• Record Type: Journal Article
• Authors: Martins, André F.; Eliseeva, Svetlana V.; Carvalho, Henrique F.; Teixeira, João M. C.; Paula, Carlos T. B.; Hermann, Petr; Platas‐Iglesias, Carlos; Petoud, Stephane; Tóth, Éva; Geraldes, Carlos F. G. C.
• Is Part Of: Chemistry. Volume 20:Issue 45(2014)
• Page Start: 14834
• Page End: 14845
• Publication Date: 2014-09-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201403856
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>We report the synthesis of a cyclen‐based ligand (4, 10‐bis[(1‐oxidopyridin‐2‐yl)methyl]‐1, 4, 7, 10‐tetraazacyclododecane‐1, 7‐diacetic acid=<bold>L1</bold>) containing two acetate and two 2‐methylpyridine <italic>N</italic>‐oxide arms anchored on the nitrogen atoms of the cyclen platform, which has been designed for stable complexation of lanthanide(III) ions in aqueous solution. Relaxometric studies suggest that the thermodynamic stability and kinetic inertness of the Gd<sup>III</sup> complex may be sufficient for biological applications. A detailed structural study of the complexes by <sup>1</sup>H NMR spectroscopy and DFT calculations indicates that they adopt an <italic>anti</italic>‐Δ(λλλλ) conformation in aqueous solution, that is, an <italic>anti</italic>‐square antiprismatic (<italic>anti</italic>‐SAP) isomeric form, as demonstrated by analysis of the <sup>1</sup>H NMR paramagnetic shifts induced by Yb<sup>III</sup>. The water‐exchange rate of the Gd<sup>III</sup> complex is <inline-formula><alternatives><tex-math notation="tex"><![CDATA[${k{{298\hfill \atop {\rm ex}\hfill}}}$]]></tex-math><inline-graphic xlink:href="ark:/27927/pgh2chp85b9" mimetype="image" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></alternatives></inline-formula>=6.7×10<sup>6</sup> s<sup>−1</sup>, about a quarter of that for the mono‐oxidopyridine analogue, but still about 50 % higher than the <inline-formula><alternatives><tex-math notation="tex"><![CDATA[${k{{298\hfill \atop {\rm ex}\hfill}}}$]]></tex-math><inline-graphic xlink:href="ark:/27927/pgh2chp85cv" mimetype="image" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></alternatives></inline-formula> of GdDOTA (DOTA=1, 4, 7, 10‐tetraazacyclododecane‐1, 4, 7, 10‐tetraacetic acid). The 2‐methylpyridine <italic>N</italic>‐oxide chromophores can be used to sensitize a wide range of Ln<sup>III</sup> ions emitting in both the visible (Eu<sup>III</sup> and Tb<sup>III</sup>) and NIR (Pr<sup>III</sup>, Nd<sup>III</sup>, Ho<sup>III</sup>, Yb<sup>III</sup>) spectral regions. The emission quantum yield determined for the Yb<sup>III</sup> complex (<inline-formula><alternatives><tex-math notation="tex"><![CDATA[${Q{{{\rm L}\hfill \atop {\rm Yb}\hfill}}}$]]></tex-math><inline-graphic xlink:href="ark:/27927/pgh2chp86bt" mimetype="image" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></alternatives></inline-formula>=7.3(1)×10<sup>−3</sup>) is among the highest ever reported for complexes of this metal ion in aqueous solution. The sensitization ability of the ligand, together with the spectroscopic and relaxometric properties of its complexes, constitute a useful step forward on the way to efficient dual probes for optical imaging (OI) and MRI.</p> </abstract>