Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report. Issue 6 (11th September 2014)

• Record Type: Journal Article
• Authors: Uehara, Ryuji; Yamashita, Koji; Hiwatashi, Akio; Togao, Osamu; Kikuchi, Kazufumi; Yokoyama, Jun; Matsuse, Dai; Yoshiura, Takashi; Honda, Hiroshi
• Is Part Of: Brain and behavior. Volume 4:Issue 6(2014:Nov.)
• Page Start: 798
• Page End: 800
• Publication Date: 2014-09-11
• Subjects: Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.282
• Languages: English
• ISSNs: 2162-3279

Abstract

<abstract abstract-type="main" id="brb3282-abs-0001"> <title>Abstract</title> <sec id="brb3282-sec-0001" sec-type="section"> <title>Objective</title> <p>We report the clinical application of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging to diagnose a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke‐like episodes (MELAS) in the acute phase.</p> </sec> <sec id="brb3282-sec-0002" sec-type="section"> <title>Results</title> <p>On IVIM MR Images of this patient, higher perfusion (f) and diffusion (D) values in the left occipital and temporal lobes were found compared to the contralateral areas.</p> </sec> <sec id="brb3282-sec-0003" sec-type="section"> <title>Conclusion</title> <p>These findings imply a breakdown of autoregulation with hyperperfusion and vasogenic edema during the acute phase of MELAS, as described in previous reports. IVIM imaging is a valuable, noninvasive tool that simultaneously quantifies perfusion and diffusion parameters.</p> </sec> </abstract>