Effects of Different Types of Bedding Materials on Behavioral Development in Laboratory CD1 Mice (Mus musculus). (3rd October 2014)

• Record Type: Journal Article
• Authors: Tanaka, Toyohito; Ogata, Akio; Inomata, Akiko; Nakae, Dai
• Is Part Of: Birth defects research. Volume 101:Number 5(2014)
• Page Start: 393
• Page End: 401
• Publication Date: 2014-10-03
• Subjects: Developmental toxicology -- Periodicals; Reproductive toxicology -- Periodicals; 616.65071
• DOI: 10.1002/bdrb.21129
• Languages: English
• ISSNs: 1542-9733

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Male and female mice were housed in cages, containing different types of bedding materials (wood flakes or pulp chips), from 4 weeks of age in the F<sub>0</sub> generation to 11 weeks of age in the F<sub>1</sub> generation; selected reproductive and neurobehavioral parameters were measured in the F<sub>1</sub> generation. There were no adverse effects of bedding materials on litter size, litter weight, or sex ratios at the time of birth. With regard to behavioral development parameters, bedding materials did not influence any variables (<italic>p</italic> > 0.05) in both sexes. Regarding exploratory behavior in the F<sub>1</sub> generation, number of defecations significantly varied (<italic>p</italic> = 0.0203) with bedding materials in males at 3 weeks of age. The number of horizontal activities also significantly varied (<italic>p</italic> = 0.0342) with bedding materials in males at 8 weeks of age. Multiple‐T water maze performance data indicated that the time required was significantly shortened across trials in pulp chips group than wood flakes group in males (<italic>p</italic> = 0.0211). Moreover, all spontaneous behavior variables in males significantly varied with bedding materials, particularly the average time of movement was significantly different (<italic>p</italic> = 0.0037) in distance between parallel lines of types of bedding materials in the F<sub>1</sub> generation. The present study shows that bedding materials influence the neurobehavioral development in mice</p> </abstract>