Alkyl pectin: Hydrophobic matrices for controlled drug release. Issue 3 (11th August 2014)

• Record Type: Journal Article
• Authors: Zheng, Xue‐Fang; Lian, Qi; Yang, Hua; Zhu, Hong
• Is Part Of: Journal of applied polymer science. Volume 132:Issue 3(2015:Feb. 05)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2014-08-11
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.41302
• Languages: English
• ISSNs: 0021-8995

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Alkyl pectin with various fatty acid (C₄–C₁₆) bromides increased its hydrophobic characteristic and made important changes in its structural features. Unmodified pectin exhibited a low degree of order (DO) and a weak tablet‐crushing strength. Pectin alkylated with a short chain length (C₄) possessed similar properties but exhibited significant swelling. Alkylation with longer side chains (C₈–C₁₆) resulted in a higher DO and crushing strength but a lower swelling. The best mechanical characteristics and drug‐release properties were found for octanoyl pectin (OP; degree of substitution = 7.06–15.41%) tablets with 20% bovine serum albumin as a tracer. The high stability of these monolithic tablets appeared to be due to hydrophobic interactions between side chains, as shown by a more organized structure. IR spectroscopy and differential scanning calorimetry analyses of OP were consistent with a hydrophobic self‐assembling model. The drug dissolution kinetics showed longer release times for higher degrees of functionalization, that is, 35 h (for 10.88% substitution) and 80 h (for 15.41% substitution); this suggested OP excipients as interesting candidates for oral and subdermal pharmaceutical applications. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. <bold>2015</bold>, <italic>132</italic>, 41302.</p> </abstract>