Inside Cover: An Organotrifluoroborate for Broadly Applicable One‐Step 18F‐Labeling (Angew. Chem. Int. Ed. 44/2014). Issue 44 (5th September 2014)

• Record Type: Journal Article
• Authors: Liu, Zhibo; Pourghiasian, Maral; Radtke, Mark Alex; Lau, Joseph; Pan, Jinhe; Dias, Gemma M.; Yapp, Donald; Lin, Kuo‐Shyan; Bénard, Francois; Perrin, David M.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 44(2014)
• Page Start: 11668
• Page End: 11668
• Publication Date: 2014-09-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201408269
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Time is the essence for ¹⁸F labeling. The poor reactivity of aqueous fluoride ions has long been a challenge in ¹⁸F labeling. In their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 11876 ff., </ext-link> D. M. Perrin et al. present trifluoroborate–peptide conjugates that are labeled by isotopic exchange in water within 15 minutes to provide ¹⁸F tracers with high specific activity. Time‐consuming HPLC can be avoided. Several bioactive ligands enable PET imaging of in vivo targets.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh2ch517jj" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>