Cooperative Catalysis with Iron and a Chiral Brønsted Acid for Asymmetric Reductive Amination of Ketones. Issue 16 (21st September 2014)

• Record Type: Journal Article
• Authors: Zhou, Shaolin; Fleischer, Steffen; Jiao, Haijun; Junge, Kathrin; Beller, Matthias
• Is Part Of: Advanced synthesis & catalysis. Volume 356:Issue 16(2014)
• Page Start: 3451
• Page End: 3455
• Publication Date: 2014-09-21
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201400328
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The direct asymmetric reductive amination (DARA) of ketones with anilines is described by combining a chiral Brønsted acid (TRIP) and the non‐chiral Knölker iron complex as the catalyst system. <italic>In situ‐</italic>formed imines are reduced with molecular hydrogen to give chiral amines in high yields (90%) and enantioselectivities of up to 99% <italic>ee</italic>.</p> <p> <boxed-text content-type="graphic" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh2ch46q67" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> </abstract>