Palladium‐Catalyzed Annulation of Diarylamines with Olefins through CH Activation: Direct Access to N‐Arylindoles1. (9th September 2014)

• Record Type: Journal Article
• Authors: Sharma, Upendra; Kancherla, Rajesh; Naveen, Togati; Agasti, Soumitra; Maiti, Debabrata
• Is Part Of: Angewandte Chemie. Volume 126:Number 44(2014)
• Page Start: 12089
• Page End: 12093
• Publication Date: 2014-09-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201406284
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A palladium‐catalyzed dehydrogenative coupling between diarylamines and olefins has been discovered for the synthesis of substituted indoles. This intermolecular annulation approach incorporates readily available olefins for the first time and obviates the need of any additional directing group. An <italic>ortho</italic> palladation, olefin coordination, and β‐migratory insertion sequence has been proposed for the generation of olefinated intermediate, which is found to produce the expected indole moiety.</p> </abstract>