Hypoxia During Sleep and the Risk of Falls and Fractures in Older Men: The Osteoporotic Fractures in Men Sleep Study. Issue 10 (3rd October 2014)

• Record Type: Journal Article
• Authors: Cauley, Jane A.; Blackwell, Terri L.; Redline, Susan; Ensrud, Kristine E.; Ancoli‐Israel, Sonia; Fink, Howard A.; Orwoll, Eric S.; Stone, Katie L.; the Osteoporotic Fractures in Men Study
• Is Part Of: Journal of the American Geriatrics Society. Volume 62:Issue 10(2014:Oct.)
• Page Start: 1853
• Page End: 1859
• Publication Date: 2014-10-03
• Subjects: Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.13069
• Languages: English
• ISSNs: 0002-8614

Abstract

<abstract abstract-type="main" id="jgs13069-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jgs13069-sec-0001" sec-type="section"> <title>Objectives</title> <p>To test the hypothesis that low arterial oxygen saturation during sleep is associated with a greater risk of falls and fractures.</p> </sec> <sec id="jgs13069-sec-0002" sec-type="section"> <title>Design</title> <p>Prospective cohort study.</p> </sec> <sec id="jgs13069-sec-0003" sec-type="section"> <title>Setting</title> <p>Six U.S. clinical centers.</p> </sec> <sec id="jgs13069-sec-0004" sec-type="section"> <title>Participants</title> <p>Men aged 67 and older (N = 2, 911).</p> </sec> <sec id="jgs13069-sec-0005" sec-type="section"> <title>Measurements</title> <p>The primary exposure measure was percentage of sleep time with arterial oxygen saturation less than 90% measured using polysomnography. The main outcome measures were incident falls within 1 year and incident nonspine fractures over an average follow‐up of 6.8 years.</p> </sec> <sec id="jgs13069-sec-0006" sec-type="section"> <title>Results</title> <p>Men with 10% or more of sleep time at an arterial oxygen saturation of less than 90% were older, reported more comorbidities, had poorer physical function, and were more likely to have sleep disordered breathing than men with less than 10% sleep time at an arterial oxygen saturation of less than 90%. After multivariate adjustment, men with 10% or more of sleep time with arterial oxygen saturation of less than 90% had a greater risk of having one or more falls (relative risk (RR) = 1.25, 95% confidence interval (CI) = 1.04–1.51) and two or more falls (RR = 1.43, 95% CI = 1.06–1.92) than those with less than 10% of sleep time with less than 90% arterial oxygen saturation. Men with greater percentage of sleep time with arterial oxygen saturation less than 90% had a 30% to 40% greater risk of nonspine fracture than those with normal nocturnal oxygen saturation in models adjusting for sleep disordered breathing.</p> </sec> <sec id="jgs13069-sec-0007" sec-type="section"> <title>Conclusion</title> <p>Hypoxia during sleep may be a risk factor for falls and fractures in older men. Interventions aimed at decreasing nocturnal hypoxia may decrease falls and fractures.</p> </sec> </abstract>