Chemokine CXCL-1 Expression in the Subretinal Fluid during Rhegmatogenous Retinal Detachment. (December 2014)

• Record Type: Journal Article
• Authors: Symeonidis, Chrysanthos; Androudi, Sofia; Rotsos, Tryfon; Moschos, Marilita M.; Souliou, Efimia; Dimitrakos, Stavros A.; Diza, Eudoxia
• Is Part Of: Ocular immunology and inflammation. Volume 22:Number 6(2014)
• Page Start: 449
• Page End: 453
• Publication Date: 2014-12
• Subjects: Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2013.863942
• Languages: English
• ISSNs: 0927-3948

Abstract

<abstract> <title>Abstract</title> <p> <italic>Purpose</italic>: To investigate the expression of chemokine CXCL-1 in the subretinal fluid (SRF) during rhegmatogenous retinal detachment (RRD) and identify potential correlations with number of quadrants involved and duration of the detachment.</p> <p> <italic>Methods and Results</italic>: Inclusion criteria were patients aged 18 years or older and primary RRD possibly complicated by proliferative vitreoretinopathy (PVR). CXCL-1 levels were measured in 36 SRF samples from 36 RRD patients. Mean CXCL-1 levels (102 ± 37 pg/mL) were significantly higher (<italic>p</italic> = 0.050) compared to controls. CXCL-1 levels correlated significantly with age (<italic>p</italic> = 0.001) and RRD duration (<italic>p</italic> = 0.002). Maximum CXCL-1 levels coincided with total RRD, 29- to 60-day duration and PVR grade C.</p> <p> <italic>Conclusions</italic>: The findings of this study may contribute to increased understanding regarding the role of CXCL-1 during the onset and progression of the wound healing process in the context of RRD and PVR.</p> </abstract>