Association Between Interleukin-8 –251A/T Polymorphism and Risk of Lung Cancer: A Meta-Analysis. (26th November 2014)

• Record Type: Journal Article
• Authors: Gao, Ping; Zhao, Hong; You, Junhao; Jing, Fangfang; Hu, Yi
• Is Part Of: Cancer investigation. Volume 32:Number 10(2014)
• Page Start: 518
• Page End: 525
• Publication Date: 2014-11-26
• Subjects: Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2014.964410
• Languages: English
• ISSNs: 0735-7907

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>This study is to evaluate the association between IL-8 –251A/T polymorphism and lung cancer risk in diverse populations. We performed a meta-analysis of six case-control studies that included 3, 265 lung-cancer cases and 3, 607 case-free controls. Overall, results showed that the IL-8 –251A/T polymorphism was not associated with a significantly increased risk of lung cancer in all genetic models. However, stratified by ethnicity, a significantly increased risk was found among Asians. In conclusion, IL-8 –251A/T polymorphism is associated with lung cancer susceptibility in Asians and the –251 A allele may increase risk of lung cancer in Asians.</p> </abstract>