Effects of different doses of letrozole on the incidence of early-onset ovarian hyperstimulation syndrome after oocyte retrieval. (December 2014)

• Record Type: Journal Article
• Authors: He, Qiaohua; Liang, Linlin; Zhang, Cuilian; Li, Hangsheng; Ge, Zhaojia; Wang, Lu; Cui, Shihong
• Is Part Of: Systems biology in reproductive medicine. Volume 60:Number 6(2014:Dec.)
• Page Start: 355
• Page End: 360
• Publication Date: 2014-12
• Subjects: Systems biology -- Periodicals; Andrology -- Periodicals; Generative organs, Male -- Diseases -- Periodicals; Biological systems -- Periodicals; Reproductive health -- Periodicals; Human reproduction -- Periodicals; 612.61
• DOI: 10.3109/19396368.2014.957879
• Languages: English
• ISSNs: 1939-6368

Abstract

<abstract> <title>Abstract</title> <p>We explored the effects of different doses of letrozole on the incidence of ovarian hyperstimulation syndrome (OHSS) after oocyte retrieval during <italic>in vitro</italic> fertilization (IVF) in patients with high-risk OHSS. A total of 88 patients were randomly divided into a control group, and groups treated with 2.5 mg, 5 mg, or 7.5 mg of letrozole. We found that from the fifth day after human chorionic gonadotrophin (hCG) treatment, the E2 level decreased and there were statistical differences between the four groups (<italic>p</italic> &lt; 0.05). From the eighth day after hCG treatment, the luteinizing hormone (LH) level increased, but the progesterone (P) level decreased. There were statistical differences between groups (<italic>p</italic> &lt; 0.05). From the fifth day after hCG treatment, the level of vascular endothelial growth factor (VEGF) increased in the control, but decreased in the letrozole groups in a dose-dependent manner. There were statistically significant differences between groups (<italic>p</italic> &lt; 0.001). The incidence of moderate and severe OHSS was lower in the 7.5 mg group than in the control group (<italic>p</italic> &lt; 0.05). In the patients with high-risk OHSS undergoing whole embryo frozen transfer, treatment with 7.5 mg letrozole may be useful to limit OHSS.</p> </abstract>