A metabolomic study of preterm and term human and formula milk by proton MRS analysis: preliminary results. (October 2014)

• Record Type: Journal Article
• Authors: Longini, Mariangela; Tataranno, Maria Luisa; Proietti, Fabrizio; Tortoriello, Mario; Belvisi, Elisa; Vivi, Antonio; Tassini, Maria; Perrone, Serafina; Buonocore, Giuseppe
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 27:Number 2(2014:Feb.)
• Page Start: 27
• Page End: 33
• Publication Date: 2014-10
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2014.955958
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To investigate changes in global metabolic profile between: 1 – breast milk and formula milk, 2 – breast milk from mothers delivering at different gestational age (GA) collected within one week from delivery, and then week by week until term equivalent age.</p> <p> <italic>Methods</italic>: Proton magnetic resonance spectroscopy (MRS) was used to analyze the water-soluble and lipid fractions extracted from 50 milk samples, 46 human milk at different GA, from 23 weeks of gestation until term equivalent age and four different formula milks.</p> <p> <italic>Results</italic>: The formula milk for premature infants was the most similar to breast milk of preterm babies. Breast milk showed higher lactose concentrations than formula milk, that conversely presented higher galactose 1-phosphate and maltose concentrations. Mother's milk of very preterm babies (23–25 wks of GA) showed a different metabolic profile from preterm infants ≥29 wks of GA with a subsequent trend to similarity around the 30th week of post-natal age. Breast milk from preterm infants of 29–34 wks, collected up to 40 wks of post-natal age showed a temporal change over the first three weeks of lactation, approaching to zero with the achievement of term age.</p> <p> <italic>Conclusions</italic>: Metabolome is a promising tool to study human and artificial milk global metabolic profile.</p> </abstract>