Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort. (November 2014)

• Record Type: Journal Article
• Authors: Weissgerber, Tracey L.; McGee, Paula L.; Myatt, Leslie; Hauth, John C.; Varner, Michael W.; Wapner, Ronald J.; Thorp, John M.; Mercer, Brian M.; Peaceman, Alan M.; Ramin, Susan M.; Samuels, Philip; Sciscione, Anthony C.; Harper, Margaret; Saade, George; Sorokin, Yoram; the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 27:Number 17(2014)
• Page Start: 1728
• Page End: 1733
• Publication Date: 2014-11
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2013.876622
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: The anti-oxidant and proangiogenic protein haptoglobin (Hp) is believed to be important for implantation and pregnancy, although its specific role is not known. The three phenotypes (1-1, 2-1 and 2-2) differ in structure and function. Hp 2-2 is associated with increased vascular stiffness in other populations. We examined whether Hp phenotype is associated with abnormal uterine artery Doppler (UAD) in pregnancy.</p> <p> <italic>Methods</italic>: We conducted a secondary analysis of a preeclampsia prediction cohort nested within a larger placebo-controlled randomized clinical trial of antioxidants for prevention of preeclampsia. We determined Hp phenotype in 2184 women who completed UAD assessments at 17 weeks gestation. Women with notching were re-evaluated for persistent notching at 24 weeks' gestation. Logistic regression was used to assess differences in UAD indices between phenotype groups.</p> <p> <italic>Results</italic>: Hp phenotype did not significantly influence the odds of having any notch (<italic>p</italic> = 0.32), bilateral notches (<italic>p</italic> = 0.72), or a resistance index (<italic>p</italic> = 0.28) or pulsatility index (<italic>p</italic> = 0.67) above the 90th percentile at 17 weeks' gestation. Hp phenotype also did not influence the odds of persistent notching at 24 weeks (<italic>p</italic> = 0.25).</p> <p> <italic>Conclusions</italic>: Hp phenotype is not associated with abnormal UAD at 17 weeks' gestation or with persistent notching at 24 weeks.</p> </abstract>