Microbial load of umbilical cord blood Ureaplasma species and Mycoplasma hominis in preterm prelabor rupture of membranes. (November 2014)

• Record Type: Journal Article
• Authors: Kacerovsky, Marian; Pliskova, Lenka; Menon, Ramkumar; Kutova, Radka; Musilova, Ivana; Maly, Jan; Andrys, Ctirad
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 27:Number 16(2014)
• Page Start: 1627
• Page End: 1632
• Publication Date: 2014-11
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2014.887068
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To evaluate <italic>Ureaplasma</italic> species and <italic>M. hominis</italic> DNA in the umbilical cord blood and its correlation with its microbial load in the amniotic fluid, as a measure of microbial burden in fetal inflammatory response and neonatal outcome in pregnancies complicated by preterm prelabor rupture of membranes (pPROM).</p> <p> <italic>Study design</italic>: A retrospective study of 158 women with singleton pregnancies complicated by pPROM between 24<sup>0/7</sup> and 36<sup>6/7</sup> weeks was conducted. Amniotic fluid was obtained from all women by transabdominal amniocentesis, and umbilical cord blood was obtained by venipuncture from umbilical cords immediately after the delivery of the neonates. The <italic>Ureaplasma</italic> species and <italic>M. hominis</italic> DNA was quantitated using absolute quantification techniques.</p> <p> <italic>Result</italic>: <italic>Ureaplasma</italic> species and <italic>M. hominis</italic> DNA was identified in 9% of the umbilical cord blood samples. No correlation between the amniotic fluid and umbilical cord blood microbial load was observed. The presence of <italic>Ureaplasma</italic> species and <italic>M. hominis</italic> DNA in the umbilical cord blood had no impact on short-term neonatal morbidity.</p> <p> <italic>Conclusions</italic>: A high microbial load of genital mycoplasma <italic>Ureaplasma</italic> species DNA in the umbilical cord in pregnancies complicated by pPROM is not associated with a high fetal inflammatory response and is therefore not associated with serious neonatal morbidity.</p> </abstract>