Long-term globular adiponectin administration improves adipose tissue dysmetabolism in high-fat diet-fed Wistar rats. (October 2014)

• Record Type: Journal Article
• Authors: Matafome, P.; Rodrigues, T.; Pereira, A.; Letra, L.; Azevedo, H.; Paixão, A.; Silvério, M.; Almeida, A.; Sena, C.; Seiça, R.
• Is Part Of: Archives of physiology and biochemistry. Volume 120:Number 4(2014)
• Page Start: 147
• Page End: 157
• Publication Date: 2014-10
• Subjects: Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.3109/13813455.2014.950590
• Languages: English
• ISSNs: 1381-3455

Abstract

<abstract> <title>Abstract</title> <p>Adiponectin administration to obese or type 2 diabetic patients is still far off, due to its expensive costs and absence of studies demonstrating the effectiveness of its chronic administration. We performed long-term globular adiponectin administration, testing its usefulness in improving adipose tissue metabolism. Adiponectin (98 υg/day) was administered through a subcutaneous minipump with continued release (28 days) to Wistar rats fed a high-fat diet. Adiponectin decreased body weight and adipocyte size, while decreasing circulating leptin levels. More, adiponectin was able to increase IkappaBalpha and PPARgamma levels and to prevent high-fat diet-induced impairment of insulin signalling, especially in epididymal adipose tissue. This resulted in improved glucose profile. High-fat diet caused an impairment of lipolysis in epididymal adipose tissue, which was partially restored by adiponectin treatment. Long-term globular adiponectin administration was able to improve pathways of insulin signalling and lipid storage in adipose tissue of high-fat diet-fed rats, contributing to a better metabolic profile.</p> </abstract>