Maternal serum apelin and YKL-40 levels in early and late-onset pre-eclampsia. (November 2014)

• Record Type: Journal Article
• Authors: Kucur, Mine; Tuten, Abdullah; Oncul, Mahmut; Acikgoz, Abdullah Serdar; Yuksel, Mehmet Aytac; Imamoglu, Metehan; Balci Ekmekci, Ozlem; Yilmaz, Nevin; Madazli, Riza
• Is Part Of: Hypertension in pregnancy. Volume 33:Number 4(2014)
• Page Start: 467
• Page End: 475
• Publication Date: 2014-11
• Subjects: Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.3109/10641955.2014.944709
• Languages: English
• ISSNs: 1064-1955

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Objective</italic>: The aim of the present study is to investigate whether alterations in the serum levels of apelin and YKL-40 differ between early and late onset pre-eclampsia and whether there is a correlation between apelin and YKL-40 in women who subsequently develop early and late pre-eclampsia. <italic>Materials and methods</italic>: A total number of 80 pregnant women, 40 with normal pregnancy and 40 with pre-eclampsia, were included in the present study. Both the normal pregnant and pre-eclamptic subjects were subdivided into two groups. Serum YKL-40 and apelin concentrations were measured. <italic>Results</italic>: Mean maternal serum YKL-40 levels were both lower in women who subsequently developed early (87.45 ± 3.07 versus 103.40 ± 4.29) or late (96.43 ± 4.06 versus 99.87 ± 3.63) pre-eclampsia than those who remained normotensive. The difference was significant in early-onset preeclamptic women (<italic>p</italic> < 0.05) rather than late-onset pre-eclamptic ones (<italic>p</italic> > 0.05). Mean maternal serum apelin levels were both higher in women who subsequently developed early (8.6 ± 3.6 versus 5.7 ± 1.2) or late (9.6 ± 2.5 versus 8.1 ± 1.8) pre-eclampsia than those who remained normotensive. The difference was significant in early-onset preeclamptic women (<italic>p</italic> < 0.05) rather than late-onset pre-eclamptic ones (<italic>p</italic> > 0.05). There was a significant negative correlation between serum apelin and YKL-40 levels (<italic>r</italic> = −0.48, <italic>p</italic> = 0.001). <italic>Conclusion</italic>: Circulating levels of apelin are significantly increased in early-onset pre-eclampsia, indicating the role of apelin in the discrimination of the early-onset of pre-eclampsia. On the other hand, maternal serum YKL-40 levels are not elavated significantly, indicating that adipose-derived apelin is primarily involved in the vascular pathogenesis of early-onset pre-eclampsia than macrophage-derived YKL-40.</p> </abstract>