Interleukin-10 Gene Polymorphisms in Recurrent Aphthous Stomatitis. (May 2014)

• Record Type: Journal Article
• Authors: Najafi, Shamsolmoulouk; Firooze Moqadam, Isaac; Mohammadzadeh, Mahsa; Bidoki, Alireza Zare; Yousefi, Hila; Farhadi, Elham; Tonekaboni, Arghavan; Meighani, Ghasem; Amirzargar, Ali Akbar; Rezaei, Nima
• Is Part Of: Immunological investigations. Volume 43:Number 4(2014)
• Page Start: 405
• Page End: 409
• Publication Date: 2014-05
• Subjects: Immunology -- Periodicals; Immunochemistry -- Periodicals; Cellular immunity -- Periodicals; Communicable diseases -- Periodicals; 616.079
• DOI: 10.3109/08820139.2014.880119
• Languages: English
• ISSNs: 0882-0139

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Recurrent aphthous stomatitis (RAS) is a common oral inflammatory disease with unknown etiology in which the immune system seems to have a role in oral tolerance. Interleukin (IL)-10 is a cytokine synthesis inhibitory factor. Single nucleotide polymorphisms (SNPs) of <italic>IL10</italic> gene could alter this cytokine production. The aim of this study was to investigate frequencies of <italic>IL10</italic> alleles and genotypes in a group of individuals with RAS. Genomic DNA of 60 Iranian patients with RAS were typed for <italic>IL10</italic> gene (C/A −1082, C/T −819, and C/A −592), using PCR-SSP method. Frequency of each allele and genotype was compared to control group.</p> <p>A significantly higher frequencies of the T allele at position −819 (<italic>p</italic> = 0.006) and the A allele at position of −592 (<italic>p</italic> &lt; 0.001) were found in the patients with RAS group, when compared to the controls. <italic>IL10</italic> GA genotype at position −1082 (<italic>p</italic> = 0.007), CA genotype at position −592 (<italic>p</italic> = 0.001), and CT genotype at position −819 (<italic>p</italic> = 0.001) were significantly higher in the RAS patients. The results of this study suggest that certain SNPs of <italic>IL10</italic> gene have association with predisposition of individuals to RAS. However, further multicenter studies should be conducted to confirm the results of this study.</p> </abstract>