Fundus Autofluorescence Imaging in Multifocal Choroiditis: Beyond the Spots. (October 2014)

• Record Type: Journal Article
• Authors: Kramer, Michal; Priel, Ethan
• Is Part Of: Ocular immunology and inflammation. Volume 22:Number 5(2014)
• Page Start: 349
• Page End: 355
• Publication Date: 2014-10
• Subjects: Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2013.855797
• Languages: English
• ISSNs: 0927-3948

Abstract

<abstract> <title>Abstract</title> <p> <italic>Purpose</italic>: To describe fundus autofluorescence (FAF) imaging and its correlation to spectral-domain optical coherence tomography (SD-OCT) in retinal areas that appear clinically noninvolved in patients with multifocal choroiditis/punctate inner choroidopathy (MFC/PIC).</p> <p> <italic>Methods</italic>: Six patients with MFC or PIC were evaluated during the disease course with multimodal imaging, which included fluorescein angiography, FAF imaging, indocyanine green angiography, and SD-OCT.</p> <p> <italic>Results</italic>: Five patients had acute and/or scarred chorioretinal spots at presentation. Five patients had choroidal neovascularization. FAF imaging in all patients disclosed diffuse peripapillary and/or posterior-pole hyperautofluorescent plaques in areas that appeared clinically to be noninvolved. Corresponding SD-OCT scans revealed severe disruption of the inner segment/outer segment junction. Findings resolved with corticosteroid treatment</p> <p> <italic>Conclusions</italic>: FAF imaging of patients with MFC/PIC reveals extensive pathology beyond the clinically apparent spots. FAF findings highlight the areas of corresponding anatomic disruption of the photoreceptor–retinal pigment epithelium complex.</p> </abstract>