Development and evaluation of pluronic- and methylcellulose-based thermoreversible drug delivery system for insulin. (November 2014)

• Record Type: Journal Article
• Authors: Nasir, Fazli; Iqbal, Zafar; Khan, Amirzada; Khan, Jamshaid A.; Khan, Abad; Khuda, Fazli; Zakir, Shahida; Yousaf, Nageen; Khan, Ismail; Shah, Yasar; Khan, Muhammad Imran; Shahbaz, Naila
• Is Part Of: Drug development and industrial pharmacy. Volume 40:Number 11(2014:Nov.)
• Page Start: 1503
• Page End: 1508
• Publication Date: 2014-11
• Subjects: Pharmaceutical chemistry -- Periodicals; Pharmaceutical industry -- Periodicals; Drug Industry -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615.05
• DOI: 10.3109/03639045.2013.831441
• Languages: English
• ISSNs: 0363-9045

Abstract

<abstract> <title>Abstract</title> <p>The objective of the current work was to develop and evaluate thermoreversible subcutaneous drug delivery system for Insulin. Thermoreversible <italic>in-situ</italic> gel system was developed and evaluated both <italic>in-vitro</italic> and <italic>in-vivo</italic> comprising of pluronic F-127 alone or in combination with methylcellulose in different ratios. The drug release kinetics and mechanism was predicted by applying various mathematical models to the <italic>in-vitro</italic> dissolution data. Rabbits were used as animal model following subcutaneous injection to predict various pharmacokinetic parameters by applying Pk-Summit® software. The <italic>in-vitro</italic> and <italic>in-vivo</italic> data revealed that the formulation IPM 15/3 consisting of the pluronic F-127 (15% w/v) and methylcellulose (3% w/v) was the most robust and capable formulation for extending the drug release and maintaining basal plasma insulin level between 10 and 40 µU/ml for 240 h (10 d).</p> </abstract>