Experimental study on the aetiology of benign paroxysmal positional vertigo due to canalolithiasis: comparison between normal and vestibular dysfunction models. Issue 1 (January 2014)

• Record Type: Journal Article
• Authors: Otsuka, K; Negishi, M; Suzuki, M; Inagaki, T; Yatomi, M; Konomi, U; Kondo, T; Ogawa, Y
• Is Part Of: Journal of laryngology & otology. Volume 128:Issue 1(2014)
• Page Start: 68
• Page End: 72
• Publication Date: 2014-01
• Subjects: Otolaryngology -- Periodicals; 617.51
• DOI: 10.1017/S0022215113003381
• Languages: English
• ISSNs: 0022-2151

Abstract

<abstract abstract-type="normal"> <title>Abstract</title> <sec id="sec1"> <title>Objectives:</title> <p>Using American bullfrog models under normal conditions and under vestibular dysfunction, we investigated whether mechanical vibration applied to the ear could induce otoconial dislodgement.</p> </sec> <sec id="sec2"> <title>Methods:</title> <p>Vibration was applied to the labyrinth of the bullfrog using a surgical drill. The time required for the otoconia to dislodge from the utricular macula was measured. Vestibular dysfunction models were created and the dislodgement time was compared with the normal models. The morphology of the utricular macula was also investigated.</p> </sec> <sec id="sec3"> <title>Results:</title> <p>In the normal models, the average time for otoconial dislodgement to occur was 7 min and 36 s; in the vestibular dysfunction models, it was 2 min and 11 s. Pathological investigation revealed that the sensory hairs of the utricle were reduced in number and that the sensory cells became atrophic in the vestibular dysfunction models.</p> </sec> <sec id="sec4"> <title>Conclusion:</title> <p>The otoconia of the utricle were dislodged into the semicircular canal after applying vibration. The time to dislodgement was significantly shorter in the vestibular dysfunction models than in the normal models; the utricular macula sustained significant morphological damage.</p> </sec> </abstract>