Effects of magnesium sulphate on coagulation after laparoscopic colorectal cancer surgery, measured by rotational thromboelastometry (ROTEM®). (5th August 2014)

• Record Type: Journal Article
• Authors: Na, H. S.; Shin, H. J.; Kang, S. B.; Hwang, J. W.; Do, S. H.
• Is Part Of: Anaesthesia. Volume 69:Number 12(2014:Dec.)
• Page Start: 1314
• Page End: 1321
• Publication Date: 2014-08-05
• Subjects: Anesthesia -- Periodicals; 617.96
• DOI: 10.1111/anae.12684
• Languages: English
• ISSNs: 0003-2409

Abstract

<abstract abstract-type="main" id="anae12684-abs-0001"> <title>Summary</title> <p>We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in patients undergoing laparoscopic colorectal cancer surgery. Patients were randomly allocated to the magnesium group (n = 22) or control group (n = 22). The magnesium group received intravenous magnesium sulphate (50 mg.kg⁻¹ followed by a continuous infusion of 15 mg.kg⁻¹.h⁻¹), whereas the control group received the same volume of isotonic saline. Mean (SD) postoperative serum magnesium levels were 1.60 (0.13) mmol.l⁻¹ in the magnesium group compared with 0.98 (0.06) mmol.l⁻¹ in the control group (p &lt; 0.001). All maximum clot firmness values of ROTEM analysis were significantly lower on the third postoperative day in the magnesium group compared with the control group (p &lt; 0.05). We conclude that ROTEM analysis demonstrated that intra‐operative administration of intravenous magnesium sulphate reduces blood hypercoagulability in patients undergoing laparoscopic colorectal cancer surgery.</p> </abstract>