In vitro and in vivo anti-cancer effects of targeting and photothermal sensitive solid lipid nanoparticles. (November 2014)

• Record Type: Journal Article
• Authors: Zhu, Xiali; Huang, Shengnan; Huang, Heqing; Zhang, Yingjie; Xie, Yingxia; Hou, Lin; Zhang, Huijuan; Shi, Jinjin; Zhang, Zhenzhong
• Is Part Of: Journal of drug targeting. Volume 22:Number 9(2014)
• Page Start: 822
• Page End: 828
• Publication Date: 2014-11
• Subjects: Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.3109/1061186X.2014.931405
• Languages: English
• ISSNs: 1061-186X

Abstract

<abstract> <title>Abstract</title> <p>This report focuses on the <italic>in vitro</italic> and <italic>in vivo</italic> anti-cancer effects evaluation of targeting and photothermal sensitive solid lipid nanoparticles (SLN) for the co-loading of docetaxel (DTX), oxidized single-walled carbon nanotubes (OSWNT) and folic acid (FA). Compared with free DTX, FA-DTX-OSWNT-SLN could efficiently cross cell membranes and afford higher antitumor efficacy on the human hepatic carcinoma cell line (SMMC-7721) <italic>in vitro</italic>. Annexin V-FITC/PI double staining further confirmed that FA-DTX-OSWNT-SLN induced higher apoptotic rates on SMMC-7721 cells. Meanwhile, the combination of near-infrared (NIR) laser irradiation at 808 nm with FA-DTX-OSWNT-SLN significantly enhanced cell inhibition. For <italic>in vivo</italic> experiments, the relative tumor volume of the sarcomaia 180 (S180) tumor-bearing mice in FA-DTX-OSWNT-SLN group was significantly smaller than that of control groups. Furthermore, when combining with NIR laser irradiation, the suppression on tumor growth was much stronger. In a word, FA-DTX-OSWNT-SLN in combination with 808 nm NIR laser could exhibit both <italic>in vitro</italic> and <italic>in vivo</italic> anti-tumor effects and may be a promising approach for cancer therapy.</p> </abstract>