Early fresh‐frozen plasma transfusion decreases the risk of retinopathy of prematurity. Issue 4 (9th October 2013)

• Record Type: Journal Article
• Authors: Dani, Carlo; Poggi, Chiara; Bresci, Cecilia; Corsini, Iuri; Frosini, Saverio; Pratesi, Simone
• Is Part Of: Transfusion. Volume 54:Issue 4(2014)
• Page Start: 1002
• Page End: 1007
• Publication Date: 2013-10-09
• Subjects: Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; Blood Group Antigens -- Periodicals; Blood Preservation -- Periodicals; Blood Transfusion -- Periodicals; 615
• DOI: 10.1111/trf.12432
• Languages: English
• ISSNs: 0041-1132

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="trf12432-sec-0001" sec-type="section"> <title>Background</title> <p>Insulin‐like growth factor 1 (IGF‐1) and IGF‐binding protein‐3 (IGFBP‐3) play a main role in the pathogenesis of retinopathy of prematurity (ROP). Fresh‐frozen plasma (FFP) from adult donors may be an actual source of IGF‐1 and IGFBP‐3 because it contains higher concentrations. The objective was to evaluate whether FFP transfusions can decrease the occurrence of ROP in a cohort of preterm infants.</p> </sec> <sec id="trf12432-sec-0002" sec-type="section"> <title>Study Design and Methods</title> <p>We retrospectively analyzed data from 218 infants with gestational age of less than 29 weeks who either received FFP or did not and correlated this procedure to the development of any grade of ROP.</p> </sec> <sec id="trf12432-sec-0003" sec-type="section"> <title>Results</title> <p>Logistic regression analysis demonstrated that two or more transfusions of FFP was effective in decreasing the risk of development of any grade of ROP (relative risk, 0.46; 95% confidence interval, 0.23‐0.93). Other factors that affected the risk of ROP were gestational age, birthweight, antenatal steroid treatment, FiO<sub>2</sub> of at least 0.40, mechanical ventilation, and sepsis.</p> </sec> <sec id="trf12432-sec-0004" sec-type="section"> <title>Conclusions</title> <p>We found that two or more transfusions of FFP in the first week of life decrease the risk of developing any grade of ROP in preterm infants with gestational age of less than 29 weeks.</p> </sec> </abstract>