The PAI‐1 4G/5G and ACE I/D Polymorphisms and Risk of Recurrent Pregnancy Loss: A Case–Control Study. (31st July 2014)

• Record Type: Journal Article
• Authors: Kim, Jin Ju; Choi, Young Min; Lee, Sung Ki; Yang, Kwang Moon; Paik, Eun Chan; Jeong, Hyeon Jeong; Jun, Jong Kwan; Han, Ae Ra; Hong, Min A
• Is Part Of: American journal of reproductive immunology. Volume 72:Number 6(2014:Dec.)
• Page Start: 571
• Page End: 576
• Publication Date: 2014-07-31
• Subjects: Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.12302
• Languages: English
• ISSNs: 1046-7408

Abstract

<abstract abstract-type="main" id="aji12302-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="aji12302-sec-0001" sec-type="section"> <title>Problem</title> <p>Thrombophilia has been postulated to be a contributor to the pathophysiology of recurrent pregnancy loss (RPL). We investigated the role of the plasminogen activator inhibitor type 1 (PAI‐1) 4G/5G and angiotensin converting enzyme (ACE) I/D polymorphisms in Korean patients with RPL.</p> </sec> <sec id="aji12302-sec-0002" sec-type="section"> <title>Method of study</title> <p>Genotyping was performed using the TaqMan assay in 227 RPL patients and 304 controls.</p> </sec> <sec id="aji12302-sec-0003" sec-type="section"> <title>Results</title> <p>The genotype distributions of both polymorphisms in the RPL group did not differ from those of controls. Because the frequency of being homozygous for ACE D/D and the PAI‐I 4G/4G combination has been reported to be significantly higher in RPL patients, this was also analyzed. However, no significant difference was noted; 3.1% of RPL patients had both ACE D/D and PAI‐I 4G/4G, as did 4.9% of controls (<italic>P </italic>=<italic> </italic>0.791).</p> </sec> <sec id="aji12302-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The current study suggests that both polymorphisms, either alone or in combination, are not major determinants of the development of RPL in Korean women.</p> </sec> </abstract>