Validation of the German version of the 'Hypogonadism Related Symptom Scale' (HRS) in andrological patients with infertility, HIV infection and metabolic syndrome. (6th January 2014)

• Record Type: Journal Article
• Authors: Alidjanov, J.; Wolf, J.; Schuppe, H.‐C.; Weidner, W.; Diemer, T.; Linn, T.; Halefeldt, I.; Wagenlehner, F.; Wiltink, J.; Pilatz, A.
• Is Part Of: Andrologia. Volume 46:Number 10(2014)
• Page Start: 1189
• Page End: 1197
• Publication Date: 2014-01-06
• Subjects: Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.12215
• Languages: English
• ISSNs: 0303-4569

Abstract

<abstract abstract-type="main" id="and12215-abs-0001"> <title>Summary</title> <p>As commonly used self‐reported screening instruments for male hypogonadism demonstrated lack of specificity, a Hypogonadism Related Symptom Scale (HRS) was developed in 2009 as a novel self‐rating screening tool. As the questionnaire has not been validated, the purpose of our study was to perform a validation in patients presenting with different disorders (e.g. infertility, HIV infection or metabolic syndrome) and disease‐related risk to develop hypogonadism. Two hundred and eighteen patients aged 19–71 years (40.1 ± 9.5) who completed the HRS and other common questionnaires [International Index Of Erectile Function (IIEF), National Institutes of Health Chronic Prostatitis Symptom Index (NIH‐CPSI), Hospital Anxiety and Depression Scale (HADS), short form (SF)‐12] were included. In all patients, blood levels of total testosterone, luteinizing hormone, follicle‐stimulating hormone, oestradiol and sex hormone‐binding globulin were determined and free testosterone was calculated. Cronbach's α for the scale was 0.896, split‐half 0.871 for the 1st half and 0.807 for the 2nd half. Spearman–Brown coefficient was 0.767, and Guttman split‐half coefficient was 0.759. Consistent correlations were found between HRS and IIEF5 (ρ = 0.57, <italic>P</italic> < 0.001), and HADS (ρ = −0.6, <italic>P</italic> < 0.001). In addition, HRS was significantly correlated with total testosterone (ρ = 0.135, <italic>P</italic> < 0.05), free testosterone (ρ = 0.148, <italic>P</italic> < 0.05) and oestradiol (ρ = −0.134, <italic>P</italic> < 0.05). Our validation study confirms the data from the initial development of the HRS questionnaire. Clinicians might have an additional advantage from the HRS when investigating males with suspected hypogonadism.</p> </abstract>