Adipose tissue distribution in relation to insulin sensitivity and inflammation in Pakistani and Norwegian subjects with type 2 diabetes. (November 2014)

• Record Type: Journal Article
• Authors: Wium, Cecilie; Eggesbø, Heidi B.; Ueland, Thor; Michelsen, Annika E.; Torjesen, Peter A.; Aukrust, Pål; Birkeland, Kåre
• Is Part Of: Scandinavian journal of clinical & laboratory investigation. Volume 74:Number 8(2014)
• Page Start: 700
• Page End: 707
• Publication Date: 2014-11
• Subjects: Clinical biochemistry -- Periodicals; Physiology, Pathological -- Periodicals; Physiology, Experimental -- Periodicals; Medicine -- Research -- Periodicals; Clinical medicine -- Periodicals; 616.0072
• DOI: 10.3109/00365513.2014.953571
• Languages: English
• ISSNs: 0036-5513

Abstract

<abstract> <title>Abstract</title> <p>Immigrants from South Asia to Western countries have a high prevalence of type 2 diabetes mellitus (T2DM) associated with obesity. We investigated the relationship between diabetes and adipose tissue distribution in a group of younger T2DM subjects from Norway and Pakistan. Eighteen immigrant Pakistani and 21 Norwegian T2DM subjects (age 29–45, 49% men) were included. They underwent anthropometrical measurements including bioelectrical impedance analysis, CT scans measuring fatty infiltration in liver and adipose and muscle tissue compartments in mid-abdomen and thigh, a euglycemic clamp, and blood samples for serum insulin and plasma glucose, adipokines and inflammation markers. Adipose tissue distribution was similar in Norwegians and Pakistanis. Pakistanis, but not Norwegians, showed a negative correlation between insulin sensitivity and visceral adipose tissue (VAT, <italic>r</italic><sub>s</sub> = − 0.704, <italic>p</italic> = 0.003). Subcutaneous adipose tissue (SAT) correlated to leptin in both Pakistanis and Norwegians (<italic>r</italic><sub>s</sub> = 0.88, <italic>p</italic> < 0.001 and 0.67, <italic>p</italic> = 0.001). SAT also correlated to C-reactive protein (CRP) in the Pakistanis only (<italic>r</italic><sub>s</sub> = 0.55, <italic>p</italic> = 0.03), and superficial SAT to Interleukin-1 receptor antagonist (IL-1RA) in Norwegians only (<italic>r</italic><sub>s</sub> = 0.47, <italic>p</italic> = 0.04). In conclusion, despite similar adipose tissue distribution in the two groups Pakistanis were more insulin resistant, with a negative correlation of VAT to insulin sensitivity, not present in Norwegians. The correlation of adipose tissue to Leptin, CRP and IL-1RA showed ethnic differences.</p> </abstract>