Identification of clinical parameters associated with serum oxidative stress in patients with rheumatoid arthritis. Issue 6 (November 2014)

• Record Type: Journal Article
• Authors: Nakajima, Arata; Aoki, Yasuchika; Shibata, Yoshifumi; Sonobe, Masato; Terajima, Fumiaki; Takahashi, Hiroshi; Saito, Masahiko; Taniguchi, Shinji; Yamada, Manabu; Nakagawa, Koichi
• Is Part Of: Modern rheumatology. Volume 24:Issue 6(2014)
• Page Start: 926
• Page End: 930
• Publication Date: 2014-11
• Subjects: Rheumatology -- Periodicals; 616.723005
• DOI: 10.3109/14397595.2014.891495
• Languages: English
• ISSNs: 1439-7595

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objectives.</italic> Reactive oxygen species <bold>(</bold>ROS) are considered to be involved in the pathobiology of rheumatoid arthritis (RA); however, their association with disease activity has not been elucidated. In this study, we measured reactive oxygen metabolites (ROM) in patients with RA using a new Free Radical Analytical System and determined clinical parameters associated with ROM.</p> <p> <italic>Methods.</italic> One hundred and fifty-two patients with RA and 80 patients with diabetes mellitus (DM) were included in this observational study. To measure ROM, the d-ROM test was performed on blood samples drawn from all subjects. The correlation between ROM and biomarkers, disease activity, doses of methotrexate (MTX), and prednisolone (PSL) were investigated.</p> <p> <italic>Results.</italic> There were significant, positive correlations between ROM and CRP, matrix metalloproteinase 3 (MMP3), Disease Activity Score 28–erythrocyte sedimentation rate (DAS28-ESR), Clinical Disease Activity Index (CDAI), and the Simplified Disease Activity Index (SDAI). Multiple regression analysis revealed that CRP and DAS28-ESR were correlated with ROM.</p> <p> <italic>Conclusions.</italic> The serum level of ROM was associated with CRP and DAS28-ESR, suggesting that ROM, in conjunction with CRP and MMP3, may be able to be used as a new biological disease marker to evaluate the disease activity of RA.</p> </abstract>