Mesenchymal chondrosarcoma diagnosed on FISH for HEY1‐NCOA2 fusion gene. Issue 5 (October 2014)

• Record Type: Journal Article
• Authors: Moriya, Kunihiko; Katayama, Saori; Onuma, Masaei; Rikiishi, Takeshi; Hosaka, Masami; Watanabe, Mika; Hasegawa, Tadashi; Sasahara, Yoji; Kure, Shigeo
• Is Part Of: Pediatrics international. Volume 56:Issue 5(2014)
• Page Start: e55
• Page End: e57
• Publication Date: 2014-10
• Subjects: Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.12407
• Languages: English
• ISSNs: 1328-8067

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Mesenchymal chondrosarcoma (MC) is an extremely rare subtype of chondrosarcoma that has a small round‐cell sarcoma with focal cartilaginous differentiation, often with a pericytomatous vascular pattern. The non‐cartilaginous components are usually dominant, and such lesions might be confused with other small round‐cell tumors. Recently, a tumor‐specific <italic>HEY1‐NCOA2</italic> fusion gene was identified in MC. Here we report the case of a 9‐year‐old boy who was diagnosed with MC by detection of <italic>HEY1‐NCOA2</italic> fusion signals in almost 50% of tumor cells in tissue sections on fluorescence <italic>in situ</italic> hybridization (FISH). In this way, the tumor was definitively diagnosed as MC. This case suggests that the detection of the <italic>HEY1‐NCOA2</italic> fusion gene on FISH is of diagnostic value for MC.</p> </abstract>