Cutaneous melanoma in patients treated with tumour necrosis factor inhibitors: a retrospective series of 15 patients. (13th December 2013)

• Record Type: Journal Article
• Authors: Chabbert, C.; Adamski, H.; Guillet, G.; Sassolas, B.; Misery, L.; Perrinaud, A.; Machet, L.; Quereux, G.; Esteve, E.; Solau‐Gervais, E.; Saraux, A.; Polard, E.; Lesimple, T.; Le Gall, F.; Dreno, B.; Dupuy, A.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 28:Number 11(2014:Nov.)
• Page Start: 1540
• Page End: 1544
• Publication Date: 2013-12-13
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.12347
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" id="jdv12347-abs-0001"> <title>Abstract</title> <sec id="jdv12347-sec-0001" sec-type="section"> <title>Background</title> <p>Several case reports suggested that tumour necrosis factor‐α (TNF) inhibitors might increase the incidence and/or alter the natural course of melanoma towards a more aggressive behaviour.</p> </sec> <sec id="jdv12347-sec-0002" sec-type="section"> <title>Objective</title> <p>Our objective was to point if history of melanoma in patients exposed to TNF inhibitors could present with a particular pattern at diagnosis or during follow‐up.</p> </sec> <sec id="jdv12347-sec-0003" sec-type="section"> <title>Methods</title> <p>We performed a retrospective multicentre study settled in the West part of France to collect and analyse all cases of patients with melanoma who received anti‐TNF therapy.</p> </sec> <sec id="jdv12347-sec-0004" sec-type="section"> <title>Results</title> <p>Fifteen cases were included. First, 10 patients (mean age: 55.6 years; sex ratio: 1) had a melanoma diagnosed after TNF inhibitors initiation. The mean duration between initiation of treatment and melanoma was 48.7 months. Two patients died of metastatic disease. Second, four patients had a past history of melanoma before anti‐TNF therapy (mean duration of treatment: 10.8 months). None experienced a progression of melanoma disease. Last, one woman had a past history of melanoma before and then developed a second melanoma when exposed to biotherapy.</p> </sec> <sec id="jdv12347-sec-0005" sec-type="section"> <title>Conclusion</title> <p>Our case series does not reveal a distinct profile of melanoma in the patients exposed to TNF inhibitors. Additional prospective trials including larger number of patient are needed to demonstrate the possible link between biological therapy with TNF inhibitors and development of melanoma.</p> </sec> </abstract>