Predictors of substance use reduction in an epidemiological first‐episode psychosis cohort. Issue 4 (24th July 2013)

• Record Type: Journal Article
• Authors: Rebgetz, Shane; Conus, Philippe; Hides, Leanne; Kavanagh, David J.; Cotton, Sue; Schimmelmann, Benno G.; McGorry, Patrick D.; Lambert, Martin
• Is Part Of: Early intervention in psychiatry. Volume 8:Issue 4(2014:Nov.)
• Page Start: 358
• Page End: 365
• Publication Date: 2013-07-24
• Subjects: Mental health -- Periodicals; Psychiatry -- Periodicals; Psychiatry -- Research -- Periodicals; Mental illness -- Prevention -- Research -- Periodicals; Mental illness -- Treatment -- Research -- Periodicals; 616.89
• DOI: 10.1111/eip.12067
• Languages: English
• ISSNs: 1751-7885

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="eip12067-sec-0001" sec-type="section"> <title>Aim</title> <p>To assess the predictors of a significant decrease or cessation of substance use (SU) in a treated epidemiological cohort of first‐episode psychosis (FEP) patients.</p> </sec> <sec id="eip12067-sec-0002" sec-type="section"> <title>Method</title> <p>Participants were FEP patients of the Early Psychosis Prevention and Intervention Centre in Australia. Patients' medical files were reviewed using a standardized file audit. Data on 432 patients with FEP and baseline co‐morbid substance use disorder (SUD) were available for analysis. Predictors of reduction/cessation of SU at follow up were examined using logistic regression analyses.</p> </sec> <sec id="eip12067-sec-0003" sec-type="section"> <title>Results</title> <p>In univariate analyses, a reduction/cessation of SU was predicted by baseline measures reflecting higher education, employment, accommodation with others, cannabis use disorder (CUD) only (rather than poly‐SUDs), better global functioning and better premorbid social and occupational functioning, later age at onset of psychosis, and a diagnosis of non‐affective psychosis. In multivariate analysis, CUD alone and better premorbid social and occupational functioning remained significant predictors.</p> </sec> <sec id="eip12067-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Addressing SUDs and social and occupational goals in people with FEP may offer opportunities to prevent SUDs becoming more severe or entrenched. Further longitudinal research on recovery from SU and FEP is needed to disentangle directions of influence and identify key targets for intervention.</p> </sec> </abstract>