Mathematical modeling of drug delivery from cylindrical implantable devices. (16th January 2014)
- Record Type:
- Journal Article
- Title:
- Mathematical modeling of drug delivery from cylindrical implantable devices. (16th January 2014)
- Main Title:
- Mathematical modeling of drug delivery from cylindrical implantable devices
- Authors:
- Ibarra, Juan C. D.
Helbling, Ignacio M.
Luna, Julio A. - Abstract:
- <abstract abstract-type="main" id="mma3007-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="mma3007-para-0001">A mechanistic mathematical model applicable to the controlled dispersed‐drug release from cylindrical device such as implantable drug delivery system was derived. Analytical solutions based on the pseudosteady state approximation are derived taken account an exact external medium volume. The model prediction is accurate when the initial drug load is higher than the drug solubility in the polymer. The results obtained are compared with the analytical solutions available in the literature. The equations are corroborated by comparison with experimental profiles reported in the literature for sink conditions and non sink conditions. The evolution of concentration distribution profiles is compared for different volume of external medium. A reduction in the volume of the external solution leads to an increase in the concentration on the surface of the device, which determines decreases in the release of drug. One criterion for determining whether the volume of external solution should be considered for the prediction of drug release from cylindrical devices is established. This criterion is based on establishing a maximum percentage error allowed in the values of amount of drug released. The usefulness of the model is focused in the design of implant for controlled release of drug into a small volume of external medium of release. Copyright © 2014<abstract abstract-type="main" id="mma3007-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="mma3007-para-0001">A mechanistic mathematical model applicable to the controlled dispersed‐drug release from cylindrical device such as implantable drug delivery system was derived. Analytical solutions based on the pseudosteady state approximation are derived taken account an exact external medium volume. The model prediction is accurate when the initial drug load is higher than the drug solubility in the polymer. The results obtained are compared with the analytical solutions available in the literature. The equations are corroborated by comparison with experimental profiles reported in the literature for sink conditions and non sink conditions. The evolution of concentration distribution profiles is compared for different volume of external medium. A reduction in the volume of the external solution leads to an increase in the concentration on the surface of the device, which determines decreases in the release of drug. One criterion for determining whether the volume of external solution should be considered for the prediction of drug release from cylindrical devices is established. This criterion is based on establishing a maximum percentage error allowed in the values of amount of drug released. The usefulness of the model is focused in the design of implant for controlled release of drug into a small volume of external medium of release. Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract> … (more)
- Is Part Of:
- Mathematical methods in the applied sciences. Volume 37:Number 17(2014:Nov. 30)
- Journal:
- Mathematical methods in the applied sciences
- Issue:
- Volume 37:Number 17(2014:Nov. 30)
- Issue Display:
- Volume 37, Issue 17 (2014)
- Year:
- 2014
- Volume:
- 37
- Issue:
- 17
- Issue Sort Value:
- 2014-0037-0017-0000
- Page Start:
- 2677
- Page End:
- 2688
- Publication Date:
- 2014-01-16
- Subjects:
- Mathematics -- Periodicals
Technology -- Mathematics -- Periodicals
519 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/mma.3007 ↗
- Languages:
- English
- ISSNs:
- 0170-4214
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5402.530000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 3835.xml