Hepatectomy for hepatocellular carcinoma in patients with hemophilia. (31st July 2014)

• Record Type: Journal Article
• Authors: Inokawa, Yoshikuni; Sugimoto, Hiroyuki; Kanda, Mitsuro; Yamada, Suguru; Fujii, Tsutomu; Nomoto, Shuji; Takeda, Shin; Suzuki, Nobuaki; Matsushita, Tadashi; Kodera, Yasuhiro
• Is Part Of: Journal of hepato-biliary-pancreatic sciences. Volume 21:Number 11(2014)
• Page Start: 824
• Page End: 828
• Publication Date: 2014-07-31
• Subjects: Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 617.556
• DOI: 10.1002/jhbp.142
• Languages: English
• ISSNs: 1868-6974

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jhbp142-sec-0001" sec-type="section"> <title>Background</title> <p>Hepatitis C virus infection due to contamination in large‐pool clotting factor concentrate is a major co‐morbidity in adult patients with hemophilia. Although the development of hepatocellular carcinoma following infection with hepatitis virus is a crucial health problem, there are few reports of hemophilia patients undergoing liver resection for hepatocellular carcinoma.</p> </sec> <sec id="jhbp142-sec-0002" sec-type="section"> <title>Methods</title> <p>Six patients with hemophilia underwent liver resection for hepatocellular carcinoma in our department from January 2003 to December 2012. We compared these hemophilic patients (H group, <italic>n</italic> = 6) to control patients without hemophilia (C group, <italic>n</italic> = 191) who underwent liver resection in the same period.</p> </sec> <sec id="jhbp142-sec-0003" sec-type="section"> <title>Results</title> <p>All six patients in the H group were hepatitis C virus positive. Administration of coagulation factors was performed perioperatively, and no differences in the operative time and estimated blood loss were observed between the groups. No postoperative complications occurred in the H group, but five patients suffered from recurrence after surgery and subsequently underwent radiofrequency ablation or transcatheter arterial chemoembolization. The median recurrence‐free survival time was 17.9 months and 25.3 months in H and C group, respectively, with no significant difference between the two groups.</p> </sec> <sec id="jhbp142-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Adequate replacement of coagulation factors enables hepatic resection for hepatocellular carcinoma patients with hemophilia.</p> </sec> </abstract>