Biological Evaluation and SAR Analysis of O‐Methylated Analogs of Quercetin as Inhibitors of Cancer Cell Proliferation. Issue 7 (27th June 2014)

• Record Type: Journal Article
• Authors: Shi, Zhi‐Hao; Li, Nian‐Guang; Tang, Yu‐Ping; Shi, Qian‐Ping; Tang, Hao; Li, Wei; Zhang, Xu; Fu, Hai‐An; Duan, Jin‐Ao
• Is Part Of: Drug development research. Volume 75:Issue 7(2014)
• Page Start: 455
• Page End: 462
• Publication Date: 2014-06-27
• Subjects: Drug development -- Periodicals; Drugs -- Research -- Periodicals; 615.19
• DOI: 10.1002/ddr.21181
• Languages: English
• ISSNs: 0272-4391

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p> <table-wrap position="anchor" orientation="portrait"> <table border="1"> <colgroup span="1"> <col align="left" span="1" /> </colgroup> <tbody> <tr> <td align="left" rowspan="1" colspan="1">Preclinical Research</td> </tr> </tbody> </table> </table-wrap> </p> <p>Using a high‐throughout screening approach, the anticancer activities of 16 <italic>O</italic>‐methylated (OMe) analogs of quercetin were assessed. The structure–activity relationships showed that OMe moieties at the 4′ and/or 7 positions were important for maintaining inhibitory activities against the 16 cancer cell lines. Furthermore, when the OH groups at the 3′ and 4′ positions were both replaced by OMe moieties, anticancer activity was enhanced.</p> </abstract>