When do the risks of repeated courses of corticosteroids exceed the risks of surgery?. Issue 11 (21st August 2014)

• Record Type: Journal Article
• Authors: Leung, Randy M.; Dinnie, Keith; Smith, Timothy L.
• Is Part Of: International forum of allergy & rhinology. Volume 4:Issue 11(2014:Nov.)
• Page Start: 871
• Page End: 876
• Publication Date: 2014-08-21
• Subjects: 617.51005
• DOI: 10.1002/alr.21377
• Languages: English
• ISSNs: 2042-6976

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="alr21377-sec-0010" sec-type="section"> <title>Background</title> <p>The management of chronic rhinosinusitis with nasal polyposis (CRSwNP) becomes unclear when patients require multiple courses of corticosteroids to maintain quality of life. Repeated courses of corticosteroids carry increased risks to patients. Although endoscopic sinus surgery (ESS) is an effective therapeutic modality, it also carries inherent risks. This study aims to identify the threshold at which the risks of repeated courses of corticosteroid exceed the risks of surgery.</p> </sec> <sec id="alr21377-sec-0020" sec-type="section"> <title>Methods</title> <p>An evidence‐based risk analysis was simulated using literature‐reported complication rates, quality of life changes, and Medicare costs. Simulations were performed from the Medicare patient perspective, societal perspective, and the universal healthcare patient perspective.</p> </sec> <sec id="alr21377-sec-0030" sec-type="section"> <title>Results</title> <p>All 3 simulations demonstrate a breakeven threshold favoring surgery over medical therapy when patients require oral corticosteroids (OCS) more often than once every 2 years in CRSwNP, once per year in CRSwNP/asthma, or twice per year for Samter's triad patients.</p> </sec> <sec id="alr21377-sec-0040" sec-type="section"> <title>Conclusion</title> <p>This represents the first rationalized evidence‐based analysis for when surgery should be considered in place of repeated courses of oral corticosteroids. This threshold provides a guide for otolaryngologists to use when making clinical decisions with patients.</p> </sec> </abstract>