Blepharoptosis and HAART Related Mitochondrial Myopathy. (December 2014)

• Record Type: Journal Article
• Authors: Chapman, Kristin Ow; Lelli, Gary
• Is Part Of: Orbit. Volume 33:Number 6(2014)
• Page Start: 459
• Page End: 461
• Publication Date: 2014-12
• Subjects: Eye-sockets -- Surgery -- Periodicals; Eye-sockets -- Diseases -- Periodicals; Orbit -- surgery -- Periodicals; Orbital Diseases -- Periodicals; 617.7
• DOI: 10.3109/01676830.2014.950289
• Languages: English
• ISSNs: 0167-6830

Abstract

<abstract> <title>Abstract</title> <p> <italic>Purpose</italic>: To report a case of blepharoptosis in a patient with human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) with biopsy confirmed mitochondrial deletions consistent with HAART related myopathy.</p> <p> <italic>Methods</italic>: A 51-year-old man with HIV demonstrated visually significant ptosis after being on HAART therapy for over 20 years.</p> <p> <italic>Results</italic>: Muscle tissue biopsy following blepharoplasty was analyzed and found to have significant mitochondrial deletions.</p> <p> <italic>Conclusions</italic>: This patient represents a case of isolated ptosis consistent with acquired myopathy secondary to mitochondrial dysfunction without systemic manifestations otherwise seen in inherited mitochondrial disorders.</p> </abstract>