Association between polymorphisms in period genes and bone density in postmenopausal Korean women. (October 2014)

• Record Type: Journal Article
• Authors: Kim, H.; Koh, H.; Ku, S-Y.; Kim, S. H.; Kim, J. H.; Kim, J. G.
• Is Part Of: Climacteric. Volume 17:Number 5(2014:Oct.)
• Page Start: 605
• Page End: 612
• Publication Date: 2014-10
• Subjects: Menopause -- Periodicals; Menopause -- Hormone therapy -- Periodicals; Menopause -- Periodicals; Estrogen Replacement Therapy -- Periodicals; Gynecology -- Periodicals; Societies, Medical -- Periodicals; 612.665
• DOI: 10.3109/13697137.2014.905527
• Languages: English
• ISSNs: 1369-7137

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic> In the present study, we aimed to investigate the association between genetic polymorphisms in period (<italic>PER</italic>) genes and bone mineral density (BMD) in postmenopausal Korean women.</p> <p> <italic>Methods</italic> The <italic>PER1 c.</italic>2247C> T and <italic>c.</italic>2884C> G polymorphisms; the <italic>PER2 c.</italic>661G> A and <italic>c.</italic>3731G> A polymorphisms; the <italic>PER3 c.</italic>2592G> A, <italic>c.</italic>3029C> T, <italic>c.</italic>3035C> T, and <italic>c.</italic>3083T> C polymorphisms, and the 54 bp variable number tandem repeats polymorphism were analyzed in 551 postmenopausal Korean women. Serum leptin, soluble leptin receptor, osteoprotegerin, soluble receptor activator of the nuclear factor-κB ligand, and bone markers including bone alkaline phosphatase and carboxy-terminal telopeptide of type I collagen were measured, and the lumbar spine and femoral neck BMDs were also determined.</p> <p> <italic>Results</italic> The <italic>PER2 c.</italic>661G> A, <italic>PER3 c.</italic>3029C> T and <italic>c.</italic>3035C> T polymorphisms were not observed. The <italic>PER2</italic> and <italic>PER3</italic> polymorphisms evaluated were not related to BMD, whereas associations of the <italic>c.</italic>2247C> T and <italic>c.</italic>2884C> G polymorphisms in <italic>PER1</italic> with the lumbar spine BMD were observed both singly and in combination. The CC haplotype homozygotes showed significantly lower lumbar spine BMD than participants with other genotypes. Additionally, 2.01-fold higher odds for osteoporosis of the lumbar spine were found in the CC haplotype homozygotes compared to women not carrying the haplotype CC allele. No significant differences in bone markers were detected according to the <italic>PER1</italic> haplotype genotype.</p> <p> <italic>Conclusions</italic> Our results suggest that both the <italic>PER1 c.</italic>2247C> T and <italic>c.</italic>2884C> G polymorphisms may be genetic factors affecting the lumbar spine BMD in postmenopausal Korean women.</p> </abstract>