Lack of association between matrix metalloproteinase-9 gene-1562C/T polymorphism and preeclampsia: a meta-analysis. (November 2014)

• Record Type: Journal Article
• Authors: Gong, Li-Li; Liu, He; Liu, Li-Hong
• Is Part Of: Hypertension in pregnancy. Volume 33:Number 4(2014)
• Page Start: 389
• Page End: 394
• Publication Date: 2014-11
• Subjects: Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.3109/10641955.2014.915033
• Languages: English
• ISSNs: 1064-1955

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Studies investigating the association between matrix metalloproteinases (MMPs) gene polymorphisms and preeclampsia (PE) reported contradictory or non-conclusive results. We performed a meta-analysis of five studies that examined the relationship between PE and the MMP9-1562C&gt;T polymorphism. The PubMed, Embase, and Google Scholar databases were searched to access the relevant genetic association studies up to September 2013. The meta-analysis revealed that there was no evidence for significant association between MMP9-1562C&gt;T polymorphism and risk of PE. Large, multiethnic confirmatory, and well-designed studies are needed to further explore the relation between preeclampsia and polymorphisms of the MMPs gene.</p> </abstract>