Dynamic changes and clinical significance of serum tryptase levels in STEMI patients treated with primary PCI. (November 2014)

• Record Type: Journal Article
• Authors: Chen, Shaomin; Mu, Di; Cui, Ming; Ren, Chuan; Zhang, Shu; Guo, Lijun; Gao, Wei
• Is Part Of: Biomarkers. Volume 19:Number 7(2014)
• Page Start: 620
• Page End: 624
• Publication Date: 2014-11
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2014.960452
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To investigate the dynamic changes in serum tryptase levels and their association with clinical data in patients with acute ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI).</p> <p> <italic>Methods</italic>: Serum tryptase levels were measured in 99 STEMI patients and 25 control subjects.</p> <p> <italic>Results</italic>: Tryptase levels were significantly increased at admission, and descended after primary PCI. Tryptase levels at 0.5, 2 and 6 h after PCI were negatively correlated with the percentage of ST-segment resolution (STR) as well as left ventricular ejection fraction (LVEF).</p> <p> <italic>Conclusions</italic>: High tryptase levels after PCI were associated with poor myocardial reperfusion and poor cardiac function.</p> </abstract>