Increased Expression of Tumor Proliferation Genes in Hispanic Women with Early-Stage Breast Cancer. (21st October 2014)

• Record Type: Journal Article
• Authors: Kalinsky, Kevin; Lim, Emerson A.; Andreopoulou, Eleni; Desai, Avni M.; Jin, Zhezhen; Tu, Yifan; Hibshoosh, Hanina; Wang, Antai; Greenlee, Heather; Crew, Katherine D.; Maurer, Matthew; Sparano, Joseph A.; Hershman, Dawn L.
• Is Part Of: Cancer investigation. Volume 32:Number 9(2014)
• Page Start: 439
• Page End: 444
• Publication Date: 2014-10-21
• Subjects: Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2014.958232
• Languages: English
• ISSNs: 0735-7907

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Onco<italic>type</italic> Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Onco<italic>type</italic> DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.</p> </abstract>