Systematic review with meta‐analysis: associations between coeliac disease and type 1 diabetes. Issue 10 (1st October 2014)

• Record Type: Journal Article
• Authors: Elfström, P.; Sundström, J.; Ludvigsson, J. F.
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 40:Issue 10(2014)
• Page Start: 1123
• Page End: 1132
• Publication Date: 2014-10-01
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.12973
• Languages: English
• ISSNs: 0269-2813

Abstract

<abstract abstract-type="main" id="apt12973-abs-0001"> <title>Summary</title> <sec id="apt12973-sec-0001" sec-type="section"> <title>Background</title> <p>In the past decade, a number of population‐based studies have examined the prevalence of coeliac disease in individuals with type 1 diabetes but prevalences have differed considerably.</p> </sec> <sec id="apt12973-sec-0002" sec-type="section"> <title>Aim</title> <p>To examine the prevalence of coeliac disease in individuals with type 1 diabetes.</p> </sec> <sec id="apt12973-sec-0003" sec-type="section"> <title>Methods</title> <p>A systematic review of English‐language articles published in PubMed Medline between 2000 and May 2014. Search terms included 'celiac disease' or 'coeliac disease' and 'diabetes mellitus'.</p> <p>Studies were selected with at least 100 individuals with type 1 diabetes being screened for coeliac disease where the coeliac diagnosis was later confirmed through small intestinal biopsy.</p> <p>Data synthesis used random‐effects inverse variance‐weighted models, and metaregression was used to examine heterogeneity in subgroups.</p> </sec> <sec id="apt12973-sec-0004" sec-type="section"> <title>Results</title> <p>A pooled analysis, based on 26, 605 patients with type 1 diabetes, found a prevalence of biopsy‐confirmed coeliac disease of 6.0% (95% CI = 5.0–6.9%). Heterogeneity was large (<italic>I</italic><sup>2</sup> = 93.2%). The prevalence was lower in adults with type 1 diabetes (2.7%), and in mixed populations with both children and adults with type 1 diabetes (4.7%) than in children (6.2%) with type 1 diabetes (<italic>P</italic> < 0.001). Additional subgroup analyses could not explain the large variation in coeliac disease prevalence between studies.</p> </sec> <sec id="apt12973-sec-0005" sec-type="section"> <title>Conclusion</title> <p>More than one in twenty patients with type 1 diabetes have biopsy‐verified coeliac disease. This prevalence is high enough to motivate screening for coeliac disease among patients with type 1 diabetes.</p> </sec> </abstract>