Staphylococcus aureus nasal carriage might be associated with vitamin D receptor polymorphisms in type 2 diabetes. (6th March 2014)

• Record Type: Journal Article
• Authors: Messaritakis, I.; Samonis, G.; Dimopoulou, D.; Maraki, S.; Papadakis, J. A.; Daraki, V.; Fragaki, M.; Choulaki, C.; Andrianaki, A. M.; Kofteridis, D. P.; Lina, G.
• Is Part Of: Clinical microbiology and infection. Volume 20:Number 9(2014:Sep.)
• Page Start: 920
• Page End: 925
• Publication Date: 2014-03-06
• Subjects: Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1111/1469-0691.12587
• Languages: English
• ISSNs: 1198-743X

Abstract

<abstract abstract-type="main" id="clm12587-abs-0001"> <title>Abstract</title> <p>Vitamin D receptor (VDR) gene polymorphisms have been associated with susceptibility to several diseases, including type 1 diabetes (T1D), type 2 diabetes (T2D), and various infections. The study investigated whether VDR gene polymorphisms influence nasal carriage of <italic>Staphylococcus aureus</italic> in individuals with T2D, an important source for bloodstream, surgical site and other nosocomial infections. In 173 patients with T2D genotyped for the VDR gene polymorphisms on <italic>Fok</italic>I (rs10735810) F>f, <italic>Bsm</italic>I (rs1544410) B>b, <italic>Apa</italic>I (rs7975232) A>a, and <italic>Taq</italic>I (rs731236) T>t, a nasal swab was obtained to detect colonization by <italic>S. aureus</italic>. A repeat swab was obtained in 162/173 subjects for the estimation of persistent <italic>S. aureus</italic> carriage. The prevalence of <italic>S. aureus</italic> nasal colonization was 19.7% and of persistent carriage was 8.6%. Nasal colonization by <italic>S. aureus</italic> was more common in individuals with <italic>Fok</italic>I f allele than F allele (p 0.05; OR 1.69, 95% CI 1.00–2.89) and individuals with <italic>Fok</italic>I ff genotypes were more frequently colonized than those with <italic>Fok</italic>I FF and Ff genotypes combined (p 0.03; OR 2.61, 95% CI 1.14–5.99). The presence of the <italic>Fok</italic>I f allele was related to higher rates of <italic>S. aureus</italic> persistent nasal colonization (p 0.002; OR 3.53, 95% CI 1.56–7.98), and individuals with a <italic>Fok</italic>I ff genotype were more often persistent carriers than those with <italic>Fok</italic>I FF and Ff genotypes combined (p <0.001; OR 7.32, 95% CI 2.39–22.41). This study is the first, to our knowledge, to show an association between <italic>Fok</italic>I polymorphism in the VDR gene and nasal carriage of <italic>S. aureus</italic> in individuals with T2D.</p> </abstract>