Prospective Trial of Sacral Neuromodulation for Refractory Overactive Bladder Syndrome in Korean Patients. Issue 3 (24th October 2013)

• Record Type: Journal Article
• Authors: MOON, Kyung Hyun; HAN, Ji‐Yeon; KIM, Jang Hwan; LEE, Ha Na; LEE, Kyu‐Sung; LEE, Jeong Gu; OH, Seung‐June; YOON, Ha Na; CHOO, Myung‐Soo
• Is Part Of: LUTS. Volume 6:Issue 3(2014)
• Page Start: 175
• Page End: 179
• Publication Date: 2013-10-24
• Subjects: Urology -- Periodicals; Urologic Diseases -- Periodicals; Urinary Tract Physiological Phenomena -- Periodicals; 616.62
• DOI: 10.1111/luts.12036
• Languages: English
• ISSNs: 1757-5664

Abstract

<abstract abstract-type="main" id="luts12036-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="luts12036-sec-0001" sec-type="section"> <title>Objectives</title> <p id="luts12036-para-0001">To evaluate the efficacy and safety of sacral neuromodulation for treating patients with refractory overactive bladder based on urodynamic data.</p> </sec> <sec id="luts12036-sec-0002" sec-type="section"> <title>Methods</title> <p id="luts12036-para-0002">Patients older than 18 years of age, with overactive bladder symptoms refractory to conventional therapies were eligible. Patients with more than a 50% reduction in frequency, urgency, or urge incontinence symptoms during a 2‐week test stimulation period retained the sacral neuromodulation. Voiding diaries, overactive bladder questionnaires, and urodynamic studies were performed before and 1 year after sacral neuromodulation.</p> </sec> <sec id="luts12036-sec-0003" sec-type="section"> <title>Results</title> <p id="luts12036-para-0003">Forty patients received sacral neuromodulation and 31 patients of those were followed more than 1 year. The mean age of the 31 patients was 54.2 ± 15.4 (range, 30–76) years, and the mean duration of symptoms was 4.4 ± 5.7 (range, 1–31) years. After 12 months of sacral neuromodulation, significant decreases in the episodes of daily urgency (from 20.2 to 5.7, <italic>P <</italic> 0.001), urgency incontinence (from 7.3 to 0.2; <italic>P =</italic> 0.011), day time micturition (from 21.8 to 9.9; <italic>P <</italic> 0.001), night time micturition (from 3.2 to 1.2; <italic>P =</italic> 0.006) and in severity of urgency episodes (from 3.8 to 2.7; <italic>P =</italic> 0.015) were observed compared to baseline. Significant increases occurred in bladder volume at the first unstable contraction (from 182.4 ± 92.7 to 216.8 ± 115.6 mL), bladder volume at first desire to void (from 150.5 ± 90.8 to 167.8 ± 81.5 mL), maximal cystometric capacity (from 260.7 ± 120.4 to 291.7 ± 124.3 mL) and bladder volume at urgency sensation (from 182.4 ± 92.7 to 208.2 ± 106.6 mL) (all <italic>P <</italic> 0.05).</p> </sec> <sec id="luts12036-sec-0004" sec-type="section"> <title>Conclusions</title> <p id="luts12036-para-0004">Sacral neuromodulation is an effective and safe treatment for refractory overactive bladder.</p> </sec> </abstract>