Peripheral and Central Venous Blood Glucose Concentrations in Dogs and Cats with Acute Arterial Thromboembolism. (16th July 2014)

• Record Type: Journal Article
• Authors: Klainbart, S.; Kelmer, E.; Vidmayer, B.; Bdolah‐Abram, T.; Segev, G.; Aroch, I.
• Is Part Of: Journal of veterinary internal medicine. Volume 28:Number 5(2014:Sep./Oct.)
• Page Start: 1513
• Page End: 1519
• Publication Date: 2014-07-16
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12400
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12400-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12400-sec-0001" sec-type="section"> <title>Background</title> <p>Acute limb paralysis because of arterial thromboembolism (ATE) occurs in cats and less commonly in dogs. ATE is diagnosed based on physical examination findings and, occasionally, advanced imaging.</p> </sec> <sec id="jvim12400-sec-0002" sec-type="section"> <title>Hypothesis/Objectives</title> <p>Peripheral, affected limb venous glucose concentration is decreased in ATE, whereas its systemic concentration is within or above reference interval.</p> </sec> <sec id="jvim12400-sec-0003" sec-type="section"> <title>Animals</title> <p>Client‐owned cats and dogs were divided into 3 respective groups: acute limb paralysis because of ATE (22 cats and 9 dogs); acute limb paralysis secondary to orthopedic or neurologic conditions (nonambulatory controls; 10 cats and 11 dogs); ambulatory animals presented because of various diseases (ambulatory controls; 10 cats and 9 dogs).</p> </sec> <sec id="jvim12400-sec-0004" sec-type="section"> <title>Methods</title> <p>Prospective observational, clinical study. Systemic and local (affected limb) blood glucose concentrations were measured. Their absolute and relative differences (ΔGlu and %ΔGlu, respectively) were compared among groups.</p> </sec> <sec id="jvim12400-sec-0005" sec-type="section"> <title>Results</title> <p>ΔGlu and %ΔGlu were significantly higher in the ATE cats and dogs groups, compared to both of their respective controls (<italic>P </italic><<italic> </italic>.0001 and <italic>P </italic><<italic> </italic>.001, respectively). No significant differences were observed between the control groups. Receiver operator characteristics analysis of ΔGlu and %ΔGlu as predictors of ATE had area under the curve of 0.96 and 0.99 in cats, respectively, and 1.00 and 1.00, in dogs, respectively. ΔGlu cutoffs of 30 mg/dL and 16 mg/dL, in cats and dogs, respectively, corresponded to sensitivity and specificity of 100% and 90% in cats, respectively, and 100% in dogs.</p> </sec> <sec id="jvim12400-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>ΔGlu and %ΔGlu are accurate, readily available, diagnostic markers of acute ATE in paralyzed cats and dogs.</p> </sec> </abstract>