Central type primitive neuroectodermal tumor/neuroblastoma of the uterus: A case report. Issue 10 (11th August 2014)

• Record Type: Journal Article
• Authors: Shimada, Chisa; Todo, Yukiharu; Okamoto, Kazuhira; Akashi, Daisuke; Yamashiro, Katsushige; Hasegawa, Tadashi
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 40:Issue 10(2014:Oct.)
• Page Start: 2118
• Page End: 2122
• Publication Date: 2014-08-11
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.12459
• Languages: English
• ISSNs: 1341-8076

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>We encountered a 63‐year‐old woman who had a uterine tumor with peritoneal dissemination and para‐aortic lymph node metastasis. Microscopic specimens of the tumor showed a small blue round‐cell tumor. Immunohistochemistry showed cells to be negative for cytokeratin AE1/3, desmin, myogenin, CD10, CD34, and CD99, focal positive for vimentin, and positive for muscle‐specific actin (HHF‐35), neurofilament, synaptophysin and CD56. Fluorescence <italic>in situ</italic> hybridization revealed no split signal showing Ewing sarcoma breakpoint region 1 gene translocation. Deletion of 1p36 was identified in 30% of the tumor cells. These findings are thought to be equivalent to central type primitive neuroectodermal tumors/neuroblastoma. Cytoreductive debulking surgery followed by chemotherapy, including cyclophosphamide, vincristine and adriamycin, resulted in complete remission. She has no evidence of disease at 24 months after surgery.</p> </abstract>