Low Levels of 25‐Hydroxy Vitamin D and Active 1, 25‐Dihydroxyvitamin D Independently Associated with Type 2 Diabetes Mellitus in Older Australian Men: The Concord Health and Ageing in Men Project. Issue 9 (12th August 2014)

• Record Type: Journal Article
• Authors: Hirani, Vasant; Cumming, Robert G.; Le Couteur, David G.; Naganathan, Vasikaran; Blyth, Fiona; Handelsman, David J.; Waite, Louise M.; Seibel, Markus J.
• Is Part Of: Journal of the American Geriatrics Society. Volume 62:Issue 9(2014:Sep.)
• Page Start: 1741
• Page End: 1747
• Publication Date: 2014-08-12
• Subjects: Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.12975
• Languages: English
• ISSNs: 0002-8614

Abstract

<abstract abstract-type="main" id="jgs12975-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jgs12975-sec-0001" sec-type="section"> <title>Objectives</title> <p>To examine the associations between serum 25‐hydroxyvitamin D (25OHD) levels and the active vitamin D metabolite, 1, 25‐hydroxyvitamin D (1, 25OHD), with type 2 diabetes mellitus (DM) in community‐living men aged 70 and older.</p> </sec> <sec id="jgs12975-sec-0002" sec-type="section"> <title>Design</title> <p>Cross‐sectional.</p> </sec> <sec id="jgs12975-sec-0003" sec-type="section"> <title>Setting</title> <p>A population‐based, cross‐sectional analysis of the baseline phase of the Concord Health and Ageing in Men Project (CHAMP), a large epidemiological study conducted in Sydney between January 2005 and May 2007.</p> </sec> <sec id="jgs12975-sec-0004" sec-type="section"> <title>Participants</title> <p>Community dwelling men aged 70 and older taking part in CHAMP (N = 1, 659).</p> </sec> <sec id="jgs12975-sec-0005" sec-type="section"> <title>Measurements</title> <p>Serum 25OHD and 1, 25OHD levels, presence of DM, age, country of birth, season of blood collection, sun exposure, body mass index, vitamin D supplement use, statin use, income, measures of health, depression, activity of daily living disabilities, parathyroid hormone, estimated glomerular filtration rate, phosphate, and calcium.</p> </sec> <sec id="jgs12975-sec-0006" sec-type="section"> <title>Results</title> <p>The prevalence of DM was 20.0%. There was a significant association between low 25OHD and 1, 25OHD levels and DM that remained after adjustment for a wide range of confounders and covariates of clinical significance such as comorbidity, renal function, calciotropic hormones, and medications.</p> </sec> <sec id="jgs12975-sec-0007" sec-type="section"> <title>Conclusion</title> <p>25OHD and 1, 25OHD levels were associated with DM. The independent association between serum 25OHD and 1, 25OHD concentrations and DM raises the question of whether each of the two vitamin D metabolites may influence DM through different biological mechanisms and pathways.</p> </sec> </abstract>